11/24/2023 0 Comments Columbus dis ms![]() In Ohio, this included offices and hospitals in Lorain and Cuyahoga counties, including the Cleveland Clinic, 8 private neurologists, and 5 hospitals. The primary data source for case ascertainment was medical records from the offices of neurologists practicing in the study area or in contiguous areas or from the neurology departments of local hospitals. ![]() In all 3 previous cluster investigations, the lack of an appropriate comparison for MS prevalence estimates precluded an assessment of the true effect of the disease. The 19-county area around Lubbock (population 424,916) was proposed to provide MS prevalence estimates for comparison with a previous MS cluster investigation conducted in El Paso, Texas ( 13). Because of the small size of Sugar Creek (population 9,915), the adjacent city of Independence (population 110,884) was included for comparison. Although refinery operations ceased in 1982, portions of the site are still used as a light-oil petroleum product marketing terminal, a pipeline facility, and an asphalt receiving and processing center. Results from a previous cluster investigation in Wellington identified 27 cases of MS for a crude point prevalence estimate of 651 per 100,000 persons, but this assessment was limited by the lack of appropriate US comparison prevalence estimates for Ohio ( 11).Īnother community, Sugar Creek, expressed similar concerns about a perceived excess of MS cases and was near an oil refinery that operated in the area from 1904 to 1982 ( 12). Lorain County (population 284,664) was included in this study because the community had expressed concerns about the frequency of MS in the city of Wellington (population 3,171) and the possible health risks of proximity to an iron foundry and plastics company. The areas we studied were Lorain County, Ohio the cities of Sugar Creek and Independence, Missouri and 19 counties surrounding Lubbock, Texas. Our goal was to determine MS prevalence estimates for 3 areas in the southern, middle, and northern United States to be used as regional comparisons for community-specific investigations of MS prevalence and as baseline estimates for studies of temporal trends in prevalence. ![]() In the past 25 years, prevalence studies of specific US locales have produced a range of estimates ( 9), up to 177 per 100,000 population in Olmstead County, Minnesota ( 10). Prevalence estimates for MS vary from 58 to 95 per 100,000 population in the United States ( 6- 8). The ability of a public health agency to enumerate cases and determine whether an excess of cases is present in a particular community is compromised by the lack of MS registries, the range of disease severity, which can affect ascertainment, and unknown background prevalence estimates. Approximately 15% of patients have primary progressive MS, in which the condition worsens gradually from disease onset and is not associated with relapses ( 5). Ultimately, most patients become disabled and may or may not have superimposed relapses (secondary progressive MS) ( 3, 4). Approximately 85% of affected people have a relapsing-remitting course, characterized by an unpredictable course of exacerbations and remissions ( 3). Multiple sclerosis (MS) is an inflammatory demyelinating disease of unknown origin it affects more than 1 million people worldwide ( 1) and disproportionately affects women and whites ( 2).
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